Synthesis, antimicrobia evaluationl and spectroscopic characterization of novel imidazolone, triazole and triazinone derivatives

Abu-Melha, Sraa (2012) Synthesis, antimicrobia evaluationl and spectroscopic characterization of novel imidazolone, triazole and triazinone derivatives. Spectrochimica Acta:Molecular and biomolecular Spectroscopy, 96. ISSN 898-905

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Abstract

The reactions of 2- phenyl -4-arylmethylene -2-oxazolin -5-ones(1a,b) and 2-phenyl-4-aryloz-2-oxazolin-5-ones(8a,b) with p-aminoazobenzene derivatives(2a-c)gave the correspondind imidazolone derivatives(4a-f)and triazole derivatives (10a-f)respectively . Also, the reaction of 1a with o- aminophenol to give the imidazolone derivative 5 was studied. The reaction of 1a with 2,4-dinitrophenylhydrazine gave the corresponding 1,2,4-triazine derivatives 14a-c,respectively. The newly synthesized compounds were screened for their antibacterial activity against Gram-positive(Bacillus subtilis and Bacillus thuringiensis). Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and in vitro antifungal potential against Fusarium oxysporum and Botrytis fabae fungal strains. The results revealed that the investigated compounds exhibited antibacterial and a significant antifungal activity.

Item Type: Article
Subjects: Chemistry
Divisions: Female College of Sciences and Arts - Khamis Mushyait > English Language
Depositing User: sara abu melha
Date Deposited: 05 Mar 2017 20:46
Last Modified: 05 Mar 2017 20:46
URI: http://eprints.kku.edu.sa/id/eprint/403

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