Reactions of Heterocyclic beta-enaminoester, Synthesis and Antimicrobial Activity of Novel PyrimidinoPyrimidine Derivatives

Abu-melha, Sraa (2014) Reactions of Heterocyclic beta-enaminoester, Synthesis and Antimicrobial Activity of Novel PyrimidinoPyrimidine Derivatives. Chemical and Process Engineering Research, 20. pp. 1-13. ISSN 2225-0913

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Abstract

In this work the corresponding 4-amino-6-pyridyl-2-phenyl-5-carbethoxypyrimidine (3) was synthesized through a one-pot, three-component reaction of pyridine-3-carbaldehyde, ethyl cyanoacetate and benzamidine hydrochloride in the presence of TEA in refluxing ethanol-DMF mixture. The synthesized pyrimidine (3) was directly transformed to medicinally important pyrimido[4,5-d]pyrimidine derivatives. All the synthesized products were tested and evaluated as antimicrobial agents. Keywords: Pyrimidine-5-ethyl carboxylate derivative, Pyrimido[4,5-d]pyrimidine, Chloroacetyl chloride

Item Type: Article
Subjects: Chemistry
Divisions: Female College of Sciences and Arts - Khamis Mushyait > English Language
Depositing User: sara abu melha
Date Deposited: 05 Mar 2017 20:49
Last Modified: 05 Mar 2017 20:49
URI: http://eprints.kku.edu.sa/id/eprint/408

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