One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

Gomha, Sobhi and Kheder, Nabila and Abdelhamid, Abdou and Mabkhot, Yahia (2016) One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents. Molecules, 21 (11). p. 1532. ISSN 1420-3049

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Official URL: http://dx.doi.org/10.3390/molecules21111532

Abstract

A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR,NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis-thiadiazole derivatives 5c,d, 7b,c and 9c had higher antitumor activity than the standard drug Imatinib.

Item Type: Article
Subjects: Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: NABILA MOHAMMED
Date Deposited: 05 Mar 2017 20:58
Last Modified: 05 Mar 2017 20:58
URI: http://eprints.kku.edu.sa/id/eprint/413

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