Evaluation of antioxidant and hepatoprotective potential of Cinnamomum tamala leaves in rats

Qureshi, Absar Ahmed (2015) Evaluation of antioxidant and hepatoprotective potential of Cinnamomum tamala leaves in rats. Saudi Journal of Health Sciences, 4 (3). pp. 156-162. ISSN 2278-1900

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Abstract

Health is one of the commonly mentioned motivations behind food choices,and functional foods offer promising health benefits. Aims: In this study, the folklore claim of Cinnamomum tamala leaves as hepatoprotective functional food is evaluated. Settings and Design: Prophylactic and curative hepatoprotective properties of selected functional food was carried out against commonly used analgesic antipyretic paracetamol(PCM). Subjects and Methods: Prophylactic and curative hepatoprotective property of suspension of C. tamala leaves (SCT) was studied against PCM‑induced hepatic damage inalbino rats. Pre‑ and post‑treatment with SCT, before and after PCM treatment, reduced the biochemical markers of hepatic damage like serum glutamic pyruvic transaminase, serumglutamic oxaloacetic transaminase, serum alkaline phosphatase, serum cholesterol, total and direct bilirubin, and tissue glutathione (GSH). Histopathological studies also revealed that pre‑ and post‑treatment with SCT, before and after PCM treatment protected the liver from PCM‑induced liver damage. In addition, an antioxidant study was carried out by in vitro lipidperoxidation. Statistical Analysis Used: Statistical analysis was performed with one‑way analysis of variance (one‑way) followed by Tukey test. Results: In this study, it has been found that prophylactic study showed better hepatoprotection than the curative study. Conclusions: In the prophylactic study, lipid peroxidation and protection of GSH may be the reason behind better hepatoprotection and C. tamala possess hepatoprotective activity possibly because of its antioxidant potential.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacist
Pharmacy
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: Absar Qureshi
Date Deposited: 16 Mar 2017 08:20
Last Modified: 16 Mar 2017 08:20
URI: http://eprints.kku.edu.sa/id/eprint/430

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