Pharmacogenetics of CYP2C19 genetic polymorphism on clopidogrel response in patients with ischemic stroke from Saudi Arabia

Adel A., Alhazzani and Murali, Munisamy and Gauthaman, Karunakaran (2017) Pharmacogenetics of CYP2C19 genetic polymorphism on clopidogrel response in patients with ischemic stroke from Saudi Arabia. Neurosciences, 22 (1). pp. 31-37. ISSN 1319-6138

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Abstract

A case-control study carried out at Neurology Clinics at Asser Central Hospital, Abha, Kingdom of Saudi Arabia from October 2015 to January 2016 and included 25 stroke patients responding to clopidogrel therapy and 25 stroke patients non responding to clopidogrel monotherapy. After obtaining their informed consent, the blood samples were collected and genotyped for CYP2C19 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP Method). Allele frequencies were derived from genotypic data and platelet aggregation was measured using multiple electrode aggregometry on the multiplate analyser. Chi Square tests, p-values, odds ratio (OR) and corresponding confidence intervals were calculated for each polymorphism.

Item Type: Article
Subjects: Medicine and Surgery
Pharmaceutical Sciences
Pharmacy
Public Health
Biology
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: GAUTHAMAN Karunakaran
Date Deposited: 05 Mar 2017 21:29
Last Modified: 05 Mar 2017 21:29
URI: http://eprints.kku.edu.sa/id/eprint/481

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