High-density lipoproteins: a novel therapeutic target for cardiovascular disease

Mohamed Saleem, TS and Sandhya Rani, PV and Gauthaman, K (2011) High-density lipoproteins: a novel therapeutic target for cardiovascular disease. Research Reports in Clinical Cardiology, 2 (212.2). pp. 1-6. ISSN 1179-8475


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Cardiovascular disease has a high rate of mortality in both Western and developing countries. Atherosclerosis and generation of reactive oxygen species through oxidative stress is the major risk factor for cardiovascular disease. Atherothrombosis with low levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein is a major risk factor for atherosclerosis-induced cardiovascular disease. Lipid-lowering drugs like statins, niacin,fibrates, and some newer agents, ie, the apolipoprotein A-I mimetics and the cholesterylester transfer protein inhibitors, not only increase HDL levels but are also effective in reducing key atherogenic lipid components, including triglyceride-rich lipoproteins. The aim of this review is to discuss the accumulating evidence suggesting that HDL possesses a diverse range of biological actions, and that increasing HDL levels by drug treatment may be beneficial in the prevention of cardiovascular disease.

Item Type: Article
Subjects: Medicine and Surgery
Pharmaceutical Sciences
Divisions: College of Pharmacy > Pharmacy
Depositing User: GAUTHAMAN Karunakaran
Date Deposited: 11 Mar 2017 12:52
Last Modified: 11 Mar 2017 12:52
URI: http://eprints.kku.edu.sa/id/eprint/486

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