ACE inhibitors – angiotensin II receptor antagonists: A useful combination therapy for ischemic heart disease

Mohamed Saleem, T S and Bharani, K and Gauthaman, K (2010) ACE inhibitors – angiotensin II receptor antagonists: A useful combination therapy for ischemic heart disease. Open Access Emergency Medicine, 2 (51). pp. 51-59. ISSN 1179-1500

[img] PDF
01071ace-inhibitors---angiotensin-ii-receptor-antagonists--a-usef_070110[1].pdf

Download (181kB)
Official URL: https://www.dovepress.com/open-access-emergency-me...

Abstract

Morbidity and mortality from cardiovascular diseases are still high, even with the use of the best available therapies. There is mounting evidence that excessive renin-angiotensin system activation triggers much of the damaging and progressive nature of cardiovascular and kidney diseases through expression of angiotensin II. Moreover, angiotensin II play a major role in the development of end organ damage through a variety of inflammatory mechanisms. Today, angiotensins-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists have clearly demonstrated their efficacy in preventing target organ damage and in reducing cardiovascular morbidity and mortality in ischemic heart disease (IHD). Moreover, the development of angiotensin II receptor antagonists has enabled a large gain in tolerability and safety. Several clinical trials have firmly established that these drugs act on the renin–angiotensin system, reducing the incidence of coronary events with monotherapy and combination therapy. In this review we summarize the role mono- and combined therapy of ACE inhibitors and angiotensin II receptor antagonists play in ischemic heart disease. In this respect the review will improve ideas for developing new formulations with combinations of these drugs in the future. Keywords: angiotensin receptor blockers, renin angiotensin system, angiotensin II

Item Type: Article
Subjects: Medicine and Surgery
Pharmaceutical Sciences
Pharmacy
Biology
Divisions: College of Pharmacy > Pharmacy
Depositing User: GAUTHAMAN Karunakaran
Date Deposited: 06 Mar 2017 06:58
Last Modified: 06 Mar 2017 06:58
URI: http://eprints.kku.edu.sa/id/eprint/487

Actions (login required)

View Item View Item