IMPACT OF STATINS IN ISCHEMIC HEART DISEASE

Vijayakumar, S and Sasikala, M and Fareedullah, Mohammed and Gauthaman, karunakaran (2011) IMPACT OF STATINS IN ISCHEMIC HEART DISEASE. International Journal of Experimental Pharmacology, 2 (1). pp. 42-48. ISSN 2248 - 9169

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Abstract

Mortality and morbidity are still high in cardiovascular disease. Myocardial ischemia reperfusion injury leading to myocardial infarction is one of the most frequent causes of the death in human. Atherosclerosis is the major risk factor for cardiovascular disease. Coronary artery disease is a common and serious condition due to an underlying pathology of atherosclerosis, which is caused mainly by increased levels of low-density lipoprotein that accumulate in the walls of the coronary arteries. The main treatment option for high cholesterol levels is a group of cholesterol-lowering drugs called HMGCoA reductase inhibitors (statins). They act mainly on the liver enzymes responsible for cholesterol synthesis, reducing the production of cholesterol. HMG-CoA reductase inhibitors (statins) have now become one of the most powerful pharmacological strategies in the treatment of cardiovascular diseases. Originally, the cardioprotective effects of statins were thought to be mediated through lipid lowering actions. However, the beneficial effects of statins in heart not only lipid lowering effects, it also having number of pleiotropic actions. Specifically in ischemic heart disease, statins have protective action through increasing the endogenous antioxidant system that can be augmented by inducing another important cellular component called Heat shock proteins (HSP) mediated through BAG-1 Modulation. Statins also have the effects on eNOS induction. In this article, we review the mechanism of cardioprotection of statins and the mechanism of potential beneficial effects of statins in ischemic heart disease.

Item Type: Article
Subjects: Medicine and Surgery
Pharmaceutical Sciences
Pharmacist
Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: GAUTHAMAN Karunakaran
Date Deposited: 13 Apr 2017 11:10
Last Modified: 13 Apr 2017 11:10
URI: http://eprints.kku.edu.sa/id/eprint/541

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