In vitro anti-yeast activity of chloramphenicol: A preliminary report

M.R.P. Joseph, R and A.M. Al-Hakami, M and M.M. Assiry, M and A.S. Jamil, S and A.M. Assiry, M and M.A. Shaker, A and M.E. Hamid, E (2014) In vitro anti-yeast activity of chloramphenicol: A preliminary report. Journal de Mycologie Médicale, 2014 (519). pp. 1-6. ISSN MYCMED-519

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Official URL: http://dx.doi.org/10.1016/j.mycmed.2014.10.019

Abstract

Chloramphenicol is a bacteriostatic antimicrobial agent but its antifungal activity is not known. The present study aimed to investigate the activity of chloramphenicol against 30 representative yeasts. The antimicrobial assay of chloramphenicol (50 mg/mL; 100 mg/mL and 200 mg/mL) was determined by the disc diffusion method using Mueller-Hinton agar against 30 representative yeast strains. Zone of inhibition was read after 48—72 h incubation at 37 8C and results were compared with some standard antifungal agents. Most of the tested yeasts (73.3%) showed inhibition zones (5 up to 35 mm) to chloramphenicol impregnated discs (200 mg/mL). Three out of the four tested Candida albicans as well as Candida famata, Candida glabrata,Candida haemolonei and Cryptococcus neoformans showed no inhibition zones to chloramphenicol (200 mg/mL). Caspofungin acetate (50 mg/mL) inhibited 83.3% of the strains; ketoconazole (200 mg/mL) 70% and metronidazole 10%. Chloramphenicol discs: 50 and 100 mg/mL showed less activity (6.7% and 36.7%, respectively) compared to the 200 mg discs; whereas chloramphenicol (BBL; 3 mg/mL) inhibited 13.3% of the strains. The anti-yeast activities of chloramphenicol were comparable to other known antifungal compounds. Moreover, it is cheap, has fewer side effectsand its inclusions in selective fungal media such as Mycosel have to be questioned.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacy
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: MAHMOUD Mahmoud
Date Deposited: 16 Mar 2017 08:42
Last Modified: 16 Mar 2017 08:42
URI: http://eprints.kku.edu.sa/id/eprint/553

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