Evaluation of Acute and Sub-Chronic Toxicities of the topical extract of Mangifriaindica Seeds on Wistar albino Rats

Amgad A. Awad El-Gied, A and Ismail M. Mahmoud, M and Abelkareem Mohammed, M and Elnazeer I Hamedelniel, I (2013) Evaluation of Acute and Sub-Chronic Toxicities of the topical extract of Mangifriaindica Seeds on Wistar albino Rats. International Journal of Research in Pharmacology and Phytochemistry (IJRPP), 3 (3). pp. 146-151. ISSN 2231-010X

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Abstract

Acute toxicity studies in animals are usually necessary for any pharmaceutical intended for humanuse. The infor￾mation obtained from these studies is useful in choosing doses for repeat-dosestudies, providing preliminary iden￾tification of target organs of toxicity, and, occasionally,revealing delayed toxicity. Acute toxicity studies may also aid in the selection of starting doses forPhase 1 human studies, and provide information relevant to acute over￾dosing in humans.The present study was designed to investigate the acute and sub-chronic toxicities of the topical extract of mangifriaindicaseed on Wistar albino rats. Toxicity study was carried out by using three different doses like 1, 2 and 4 mg/kg/day. Several parameters like aspartate transaminase, alanine transaminase, alkaline phos￾phatase, totoal protein, albumin, total bilirubin, direct bilirubin, urea, hemoglobin, red blood cell, packed cell voume, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cell, lymphocytes, granulocytes and histopathology of liver, kidney, heart and spleen. The extract in all the doses produced signifi￾cant protection and offered the therapeutic profile related to Mangiferaindica extract.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacy
Depositing User: Amged Algied
Date Deposited: 13 Apr 2017 11:27
Last Modified: 13 Apr 2017 11:27
URI: http://eprints.kku.edu.sa/id/eprint/592

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