Development of floating matrix tablets of losartan potassium: in vitro and in vivo evaluation

MOHAMED, RAHAMATHULLA and S, S. Saisivam and F, Shakeel (2013) Development of floating matrix tablets of losartan potassium: in vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology, 23 (6). pp. 611-617. ISSN 1773-2247


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The aim of the present study was to develop floating matrix tablets of losartan potassium (LP). The floating matrix tablets of LP were prepared using different proportion of hydroxypropyl methyl cellulose (HPMC-K4M) and karaya gum. The prepared tablets were evaluated for various pre-compression & post-compression parameters, in vitro drug release and in vivo X-ray imaging in rabbits. All tablets showed excellent swelling and floating capabilities, short floating lag times and maintained controlled release for more than 16 h. The release of LP from optimized formulation F9 was found to be non-Fickian type. Gastric X-ray imaging of formulation F9 (containing LP/HPMC-K4M/karaya gum/microcrystalline cellulose/sodium bicarbonate/magnesium stearate/lactose) showed that the floating matrix tablet was continuously floating in the stomach region of the rabbit; hence, it could prolong the gastric retention time to more than 12 h. These results indicated that developed matrix tablets of LP could be successfully used for floating drug delivery system.

Item Type: Article
Subjects: Pharmaceutical Sciences
Divisions: College of Pharmacy > Pharmacy
Depositing User: DR shukoorulla mohamed
Date Deposited: 24 Apr 2017 08:42
Last Modified: 24 Apr 2017 08:42

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