BENEFITS AND PITFALLS OF USING INSULIN IN THE MANAGEMENT OF TYPE 2 DIABETES PATIENTS: A CLINICAL EVALUATION

Sirajudeen. S.alavudeen, S and Dr.C.K Dhanapal, D and Dr.Khaled M.Al Akhali, K and Noohu Abdulla Khan, N and Dr.V.V.Venkatachalam, V (2014) BENEFITS AND PITFALLS OF USING INSULIN IN THE MANAGEMENT OF TYPE 2 DIABETES PATIENTS: A CLINICAL EVALUATION. Journal of Applied Pharmacy, 6 (4). pp. 416-426. ISSN 1920-4159; ICDTD Inc. SK Canada

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Abstract

Introduction: Type 2 diabetes is associated with a range of cardiovascular risk factors. Insulin therapy has several metabolic benefits. However, large doses of insulin are often required to achieve near normal blood glucose levels and are associated with weight gain and the risk of hypoglycemia. Objectives: To evaluate the efficacy and safety of insulin monotherapy in type II diabetes patients whose glycemic control was not maintained by the oral hypoglycemic agents (OHAs). Methods: single-centre, observational retrospective study conducted at Asir Diabetes Center from June 2012 to June 2013 evaluating the efficacy and safety of the insulin monotherapy in type 2 diabetics. Results: At study end, the mean HbA1c value was reduced from 9.7± 2.2 % to 8.4± 1.5 %. FBG was decreased from 183.7± 73.02 mg/dl to 183.7± 73.02 mg/. 14.5 % of patients achieved HbA1c ≤7%. 27.5% of patients achieved the target fasting blood glucose level (≤110 mg/dl). 34.8% of patients had confirmed hypoglycemia. Conclusion: Insulin monotherapy therapy has shown significant reduction in the HbA1c value, fasting plasma glucose level, post prandial glucose level and lipid levels and thereby a reduction in the long-term complications of diabetes.

Item Type: Article
Subjects: Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: KHALED ALAKHALI
Date Deposited: 01 May 2017 09:23
Last Modified: 01 May 2017 09:23
URI: http://eprints.kku.edu.sa/id/eprint/737

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