Evaluation of drug release kinetics for diclofenac sodium 100 mg origin brand matrix tablet

Adulkarim K. Al Zomor, A and Khaled M. Al Akhaly, K (2012) Evaluation of drug release kinetics for diclofenac sodium 100 mg origin brand matrix tablet. Asian Journal of Pharmacy and Life Science, 2 (2). pp. 267-279. ISSN 2231-4423

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24. EVALUATION OF DRUG RELEASE KINETICS FOR DICLOFENAC SODIUM 100MG ORIGIN BRAND.pdf

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Abstract

The development of controlled release drug delivery systems has increased, the release of drug from the dose is the most important step in controlled release dosage form design and to confirm the release is done properly, the kinetic study must be take placed which described the overall release of drug from the dosage forms, because qualitative and quantitative changes in a formulation may alter drug release and in vivo performance, developing tools that facilitate product development by reducing the necessity of bio-studies is always desirable. In this regard, the use of in vitro drug dissolution data to predict in vivo bio-performance can be considered as the rational development of controlled release formulations. The aim of this study is to evaluate drug release parameters as per various release kinetic models. The tablets were characterized by physical and chemical parameters and results of assay% for the three batches were found as 102.07(S.D = 1.11), 99.87(S.D = 1.45) and 100.52 (S.D = 1.72).within acceptable limits (90- 110%). Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model was based on linearity (coefficient of correlation). The drug release data for drug fit well to the by zero order kinetics which give the highest r2 value (0.993), with anomalous release mechanism

Item Type: Article
Subjects: Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: KHALED ALAKHALI
Date Deposited: 01 May 2017 09:31
Last Modified: 01 May 2017 09:31
URI: http://eprints.kku.edu.sa/id/eprint/745

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