Stereoselective Synthesis of (-)-Pironetin by an Iterative Prins Cyclisation and Reductive Cleavage Strategy

J.S, Yadav and Ather, Hissana and N, Venkateswar Rao and M, Sridhar Reddy and A.R, Prasad (2010) Stereoselective Synthesis of (-)-Pironetin by an Iterative Prins Cyclisation and Reductive Cleavage Strategy. Synlett, 2010 (8). pp. 1205-1208. ISSN 0936-5214

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Abstract

A stereoselective synthesis of pironetin, a natural product which is highly immunosuppressive and shows remarkable plant growth regulatory and antitumoral activities, is described. The approach avails successfully the high stereoselection of Prins cyclisation. The route relies, in addition, on the reductive opening of cyclic ethers, olefin metathesis, and lithium acetylide displacement of tosylate. Key words natural products - Prins cyclisation - stereoselective synthesis - reductive cleavage - olefin metathesis

Item Type: Article
Subjects: Chemistry
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: DR HISSANA ATHER MOHAMMED MAZHER
Date Deposited: 20 Aug 2017 07:21
Last Modified: 20 Aug 2017 07:21
URI: http://eprints.kku.edu.sa/id/eprint/853

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