Stereoselective Total Synthesis of (-)-Colletol by Prins Cyclisation

Jhillu S, Yadav and N, Mallikarjuna Reddy and P, Adi Narayana Reddy and Ather, Hissana and Attaluri R, Prasad (2010) Stereoselective Total Synthesis of (-)-Colletol by Prins Cyclisation. Synthesis, 2010 (9). pp. 1473-1478. ISSN 0039-7881

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Abstract

A simple and efficient asymmetric total synthesis of the bis-macrolactone (-)-colletol was accomplished, proving the versatility of the Prins cyclisation in natural product synthesis. The synthesis mainly relies upon reductive opening of a pyran ring, Mitsunobu inversion, the Wittig reaction, and Yamaguchi macrolactonisation as the key steps.

Item Type: Article
Subjects: Chemistry
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: DR HISSANA ATHER MOHAMMED MAZHER
Date Deposited: 14 May 2017 21:21
Last Modified: 14 May 2017 21:21
URI: http://eprints.kku.edu.sa/id/eprint/856

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