Comparison of Efficacy and Safety of Basal and Premixed Insulin Regimens among Type II Diabetes Patients Transiting From Oral Agents to Insulin

S.A, Sirajudeen and C.K, Danapal and Abdulla, N.K and MA, Khalid (2013) Comparison of Efficacy and Safety of Basal and Premixed Insulin Regimens among Type II Diabetes Patients Transiting From Oral Agents to Insulin. Indian Journal of Pharmacy Practice, 6 (4). pp. 27-32. ISSN 0974-8326

[img]
Preview
PDF
Comparison of Efficacy and Safety of Basal and Premixed Insulin Regimens among Type II Diabetes Patients.pdf

Download (924kB) | Preview
Official URL: http://www.ijopp.org

Abstract

Introduction: Achievement and maintenance of tight glycemic control in type II diabetes require insulin when oral hypoglycemic agents fail to achieve target HbA1C. There is a lack of uniform consensus as to which of the regimens should be recommended to initiate insulin treatment in these patients. Objectives: To compare the efficacy and safety of adding basal insulin to oral agents versus switching to twice-daily premixed insulin in type II diabetic patients insufficiently controlled by oral hypoglycemic agents(OHAs). Research design and methods: This was a single-centre,retrospective study comparing glargine+OHA with premixed 70/30 regimen in patients with type II diabetes whose glycemic targets were not achieved with the use of oral hypoglycemic agents. Results: A total of 138 subjects were eligible for this study. At study end, the mean HbA1c value was lower in the premix 70/30 than in glargine+OHA(8.07±0.15vs.8.44±0.17 %, P<0.0001). The HbA1c reduction was greater in the premix 70/30 than glargine+OHA (-2.316±0.25vs. - 2.489±0.24%,respectively;P<0.0001). More premix70/30 treated subjects reached target HbA1c values than glargine treated subjects (HbA1c≤7.0%: 31.4% vs.26.5%. Similarly, FBG decrease was greater with premix70/30 (mean difference -54.68 ±17.93vs -68.57±9.178, P< 0.0001), and more patients reached target FBG≤ 110 mg/dl with premix 70/30 than with glargine+OHA (30% vs25%). Premix 70/30 patients had fewer confirmed hypoglycemic episodes than glargine+OHA patients (14.3% and 20.6% respectively). Conclusion: Based on the results, premixed biphasic 70/30 appears to be more effective than insulin glargine+OHA and a reasonable choice to initiate insulin therapy in insulin-naive subjects with type 2 diabetes that is not optimally controlled on OHA. Keywords: Diabetes, OHA, retrospective, FBG, HbA1c

Item Type: Article
Subjects: Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: SIRAJUDEEN Shaik
Date Deposited: 05 Jun 2017 09:18
Last Modified: 05 Jun 2017 09:18
URI: http://eprints.kku.edu.sa/id/eprint/914

Actions (login required)

View Item View Item