Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats

Ramachandra Setty, S. and Quereshi, Absar Ahmed and Viswanath Swamy, A.H.M. and Patil, Tushar and Prakash, T. and Prabhu, K. and Veeran Gouda, A. (2007) Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia, 78 (7-8). pp. 451-454. ISSN 0367326X

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Official URL: http://dx.doi.org/10.1016/j.fitote.2006.11.022

Abstract

Hydro-ethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, cholesterol, HDL and tissue GSH were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGPT, SGOT, ALP, bilirubin and cholesterol levels and reduced the serum levels of HDL and tissue level of GSH. Treatment with hydro-ethanolic extract of C. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacist
Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: Dr. Absar Qureshi
Date Deposited: 08 Jun 2017 11:02
Last Modified: 08 Jun 2017 11:02
URI: http://eprints.kku.edu.sa/id/eprint/916

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