Hepatoprotective and antioxidant activities of flowers of Calotropis procera (Ait) R. Br. in CCl4 induced hepatic damage

Qureshi, Absar Ahmed and T, Prakash and Patil, Tushar and Swamy, A H M Viswanath and Gouda, Veeran A and K, Prabhu and Setty, Ramachandra S (2007) Hepatoprotective and antioxidant activities of flowers of Calotropis procera (Ait) R. Br. in CCl4 induced hepatic damage. Indian Journal of Experimental Biology, 45. pp. 304-310. ISSN 0975-1009 (Online); 0019-5189 (Print)

[img] PDF
IJEB 45(3) 304-310.pdf

Download (224kB)
Official URL: http://www.niscair.res.in/sciencecommunication/res...

Abstract

Hepatoprotective activity of 70% ethanolic extract of flowers of C. procera was studied against CCl4 induced hepatic injury in albino rats and mice. In addition, antioxidant activity was studied by in vitro models. Pre-treatment with 70% ethanolic extract (CPA) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, bilirubin, cholesterol, HDL and tissue glutathione (GSH) levels. Similarly pretreatment with CPA reduced the CCl4 induced elevation in the pentobarbitone sleeping time. Histopathological observations also revealed that pretreatment with CPA protected the animals from CCl4 induced liver damage. CPA demonstrated dose dependant reduction in the in vitro and in vivo lipid peroxidation induced by CCl4. In addition it showed dose dependant free radical scavenging activity. The results indicate that flowers of C. procera possess hepatoprotective property possibly because of its anti-oxidant activity. This property may be attributed to the quercetin related flavonoids present in the flowers of Calotropis procera.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacist
Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: Dr. Absar Qureshi
Date Deposited: 20 Aug 2017 08:46
Last Modified: 20 Aug 2017 08:46
URI: http://eprints.kku.edu.sa/id/eprint/917

Actions (login required)

View Item View Item