In vitro and in vivo evaluation of oxatomide β-cyclodextrin inclusion complex

hashem, fahima. m and mosata, mohamed and naser, mohamed and Shaker, Mahmoud A. (2013) In vitro and in vivo evaluation of oxatomide β-cyclodextrin inclusion complex. Journal of Pharmaceutics, 2013 (629593). 629593-9 pages. ISSN 10.1155/2013/629593 (Submitted)

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Official URL: http://dx.doi.org/10.1155/2013/629593

Abstract

The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques. The co-evaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency (P < 0.05) compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated that 73.15 % increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide with β-cyclodextrin prepared by co-evaporation in presence of PVP-K15 results not only in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.

Item Type: Article
Subjects: Pharmaceutical Sciences
Pharmacy
Divisions: College of Pharmacy > Pharmaceutical Sciences
Depositing User: MAHMOUD Mahmoud
Date Deposited: 23 Aug 2017 08:50
Last Modified: 23 Aug 2017 08:50
URI: http://eprints.kku.edu.sa/id/eprint/966

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