FORMULATION AND OPTIMIZATION OF EXEMSTANE NIOSOMES

Sathali, Abdul Hasan and GS, Prasad and C, Vijaya (2012) FORMULATION AND OPTIMIZATION OF EXEMSTANE NIOSOMES. Int. J. Pharmacol. Bio. Sci., 6 (1). pp. 39-56. ISSN 0973-6808

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Abstract

iosome drug delivery system containing exemestane. Exemestane niosomes were formulated by thin film hydration method using different ratios of nonionic surfactants (Span 20, 40, 60 and 80) and cholesterol with constant drug concentration. The products were evaluated for physicochemical parameters such as entrapment efficiency, vesicle size morphological characters and zeta potential measurement. From the result it was concluded that higher entrapment efficiency was obtained with Span 60 niosomes (1:1 ratio) and the release rate at 12 hrs was found to be 59.1%.The mechanism of release from Span 60 1:1formulations obeyed Higuchi model release and followed zero order release kinetics. Fourier Transform Infra-Red (FT-IR) Spectroscopy and Differential Scanning Calorimetry (DSC) studies were carried out to study the compatibility between the drug and excipients. These studies, suggest that the formulation components non-ionic surfactants (Span 20, 40, 60 and 80) cholesterol and the drug exemestane do not interact to form any additional chemical entity but remain as physical mixture. Further, selected formulations were stabilized by adding charge inducing agents such as stearylmine and dicetyl phosphate (DCP) and the results suggested that the niosomes with DCP found to be more stable. Formulation (F19) (1:1) was subjected to stability studies as per International Conference on Harmonization (ICH) guidelines. Niosomes can be formulated by proper adjustment of process parameters to enhance drug entrapment and sustainability of release. In conclusion, the niosomal formulation could be a promising delivery system for exemestane with a prolonged drug release profiles and possible improved bioavailability

Item Type: Article
Subjects: Pharmacy
Divisions: College of Pharmacy > Pharmacy
Depositing User: س� تش�
Date Deposited: 23 Aug 2017 08:51
Last Modified: 23 Aug 2017 08:51
URI: http://eprints.kku.edu.sa/id/eprint/972

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