Relationship Between Postprandial Endotoxemia in Pre and Post Menopausal Women After a Fat Overload

Zaman, Gaffar Sarwar and Amanullah, Mohammed and Zaman, Fawziz (2014) Relationship Between Postprandial Endotoxemia in Pre and Post Menopausal Women After a Fat Overload. International Journal of Basic and Applied Medical Sciences, 4 (2). pp. 111-121. ISSN 2277-2103

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Abstract

Bacterial endotoxemia has been associated with postprandial lipemia, though this relation is not fully understood. The objective of this study was designed to test the hypothesis that young premenopausal (PrW) and postmenopausal women (PoW) may be independently associated with postprandial endotoxemia and indirectly associated with atherosclerosis. The lipopolysaccharide (LPS) levels and circulating lipopolysaccharide-binding protein (LBP) were determined in serum at fasting, 1 hr, 2 hrs, 3 hrs, and 4 hrs after a fat overload and their levels related with postprandial lipid levels in 70 premenopausal women and 70 post-menopausal women. The postmenopausal women with the highest postprandial hypertriglceridemia showed a significant increase in LPS levels and circulating LBP in serum after the fat overload. Elevated LPS and circulating LBP was associated significantly with PoW, especially after a fat overload. These findings suggested a role of LPS and LBP in atherosclerosis. Prospective studies are needed to confirm these results.

Item Type: Article
Subjects: Medical laboratory
Divisions: College of Applied Medical Sciences > Medical laboratory
Depositing User: DR GAFFAR SARWAR ZAMAN
Date Deposited: 26 Nov 2017 11:58
Last Modified: 26 Nov 2017 11:58
URI: http://eprints.kku.edu.sa/id/eprint/1401

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