Development of Phage Biopanning and Binding Assays for a Better Selection of Hepatitis C Virus Peptide Inhibitors.

Hakami, Abdulrahim (2014) Development of Phage Biopanning and Binding Assays for a Better Selection of Hepatitis C Virus Peptide Inhibitors. In: 8th Saudi Student Conference (SSC), 31 Jan - 1 Feb 2014, Queen Elizabeth II Conference Centre, London. (Unpublished | غير منشور)

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Abstract|ملخص البحث

Hepatitis C Virus (HCV) is one of the leading causes of chronic hepatitis and hepatocellular carcinoma. Given the side effects of the current treatment, novel anti-viral therapies are highly needed to combat viral hepatitis and minimize the adverse effects. Phage display is a powerful technique for selecting random peptides fused to bacteriophage surface proteins from a library of different sequences. These peptide libraries are screened for specific binding to target proteins. Sequencing of the selected phage genome is used to determine the 12-mer peptide presented on the phage.1,2. The study aims to develop and improve phage selection experiments and identify peptides capable of high affinity binding to HCV E2 glycoprotein. Biopanning using a variety of random peptide phage display libraries and assessing their potential to inhibit HCV entry was performed.

Item Type|تصنيف النتاج العلمي: Conference or Workshop Item | مؤتمرات وورش عمل (Poster)
Subjects | مجال موضوع النشر: Medical laboratory
Divisions | الكلية: College of Applied Medical Sciences > Medical laboratory
Depositing User: Dr Abdulrahim Hakami
Date Deposited: 05 Mar 2019 08:15
Last Modified: 05 Mar 2019 08:15
URI: http://eprints.kku.edu.sa/id/eprint/3004

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