Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors

Haiba,, ME and Al-Abdullah,, ES and Edrees,, MM and Khalifa,, NM (2014) Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. DRUG RESEARCH, 65 (1). pp. 9-17. ISSN 2194-9379

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Abstract|ملخص البحث

Khelline is naturally occurring furochromone exhibited significant Epidermal Growth Factor Receptor (EGFR) inhibitory activity. The newly synthesized compounds 2-5 displayed the most potent EGFR inhibitory activity on MCF-7 and HeLa. In vitro study against 59 different human tumour cell lines derived from nine cancer type in NCI (USA), which was presented and documented. Molecular docking simulation was performed to position compounds 1-5 into the EGFR active site to determine the probable binding mode.

Item Type|تصنيف النتاج العلمي: Article| منشور علمي
Subjects | مجال موضوع النشر: Chemistry
Depositing User: Mastoura M. Edrees
Date Deposited: 11 Mar 2019 07:03
Last Modified: 11 Mar 2019 07:03
URI: http://eprints.kku.edu.sa/id/eprint/3529

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