Quercetin effects on chronic unpredictable stress-induced brain damage

Bin-Jaliah, Ismaeel (2014) Quercetin effects on chronic unpredictable stress-induced brain damage. In: The First Pan-American Congress of Physiological Sciences themed “Physiology without Borders”, co-organised by the International Union of Physiological Sciences (IUPS) and the American and World Physiological Societies, August 2014, Foz do Iguassu, Parana, Brazil.

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Official URL | رابط موقع المجلة: http://www.the-aps.org/mm/Publications/Journals/Ph...

Abstract|ملخص البحث

Stress is known to alter the cellular homeostasis in brain and may and may involve various forms of neurotoxicity including neuronal death. The particular effects of experimental chronic unpredictable stress (CUS) in brain damage are poorly studied. This study aims to examine the oxidative and nitrosative damage, inflammation, and involvement of Bcl-2 and caspase 3 in CUS-induced brain damage, and to investigate the preventive role of the flavonoid Quercetin (QUR) against such damage. Forty rats were randomized into 4 groups (n=10; each): Control+vehicle, Control+ QUR, CUS+vehicle, and CUS+QUR. CUS was applied for 3 weeks, during which the vehicle (NS) or QUR (50 mg/kg) were i.p. administered daily. Data are expressed as means ±SD, and significant differences were recognised at (P< 0.05). In the brains of the CUS stressed rats, there were significant elevations in the levels of MDA (2.3±0.04 vs. 0.98±0.04 uM), TNF-α (2.9±0.42 vs. 0.81±0.21 pg/mg), IL-6 (38.2±4.7 vs. 18.7±2.2 pg/mg), iNOS (5.4±2.4 vs. 3.1±0.48 pg/mg) and caspase 3 (0.50±0.04 vs. 0.15±0.02 ng/mg), with concomitant significant decreases in the activities of SOD (10.8 ±0.76 vs. 25.6 ±2.9 U/mg) and GPX (80.2±4.9 vs. 121.6+8.2 nmol/min/ml) and levels of Bcl-2 (2.9±0.49 vs. 7.8±0.63 ng/mg). QUR treatment to CUS stressed brought all of these parameters to control levels. These data hypothesizes that supplementation with Quercetin ameliorates CUS-induced brain damage by its anti-oxidant, anti-inflammatory and anti-apoptotic potentials.

Item Type|تصنيف النتاج العلمي: Conference or Workshop Item | مؤتمرات وورش عمل (Poster)
Subjects | مجال موضوع النشر: Medicine and Surgery
Biology
Divisions | الكلية: College of Medicine > Physiology
Depositing User: Prof. Ismaeel Bin-Jaliah
Date Deposited: 28 Dec 2018 18:10
Last Modified: 28 Dec 2018 18:10
URI: http://eprints.kku.edu.sa/id/eprint/4136

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