Resveratrol effects on chronic unpredictable stress-induced gastric ulcer

Bin-Jaliah, Ismaeel (2014) Resveratrol effects on chronic unpredictable stress-induced gastric ulcer. In: The First Pan-American Congress of Physiological Sciences themed “Physiology without Borders”, co-organised by the International Union of Physiological Sciences (IUPS) and the American and World Physiological Societies, August 2014, Foz do Iguassu, Parana, Brazil.

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Abstract|ملخص البحث

Stress of various models has been linked to gastric mucosal damage. The polyphenol Resveratrol (RES) has been reported to have anti-ulcer properties against some models of gastric ulcer. However, its effect against experimental chronic unpredictable stress (CUS)-induced ulcer per se was not studied before. This study aims to investigate the gastric mucosal damage induced by CUS and its potential prevention by RES. Forty rats were randomized into 4 groups (n=10; each): Control+vehicle, Control+ RES, CUS+vehicle, and CUS+RES. CUS was applied for 3 weeks, during which the vehicle (NS) or RES (25 mg/kg) were i.p. administered daily. Ulceration index, oxidative, inflammatory and apoptotic parameters were measured. Data are expressed as means ±SD, and significant differences were recognized at (P< 0.05). CUS induced severe gastric lesions of various lengths. In the stomachs of the CUS stressed rats, there were significant elevations of MDA (3.5±0.5 vs. 1.8±0.1 uM), TNF-α (3.9±0.4 vs. 1.8±0.2 pg/mg), IL-6 (55.7±8.8 vs. 29.4±3.6 pg/mg) and caspase-3 (0.5±0.07 vs. 0.15±0.01 ng/mg) with concomitant significant decreases of SOD (4.8 ±0.7 vs. 11.2 ±0.7 U/mg), GPX (120±11 vs. 197±16 nmol/min/ml) and Bcl-2 (2.8±0.5 vs. 5.7±0.6 ng/mg) with no changes in iNOS. RES treatment to CUS stressed rats brought all of these parameters to control levels. These data shows that supplementation with resveratrol ameliorates CUS-induced ulcer via its anti-oxidant, anti-inflammatory and anti-apoptotic potentials.

Item Type|تصنيف النتاج العلمي: Conference or Workshop Item | مؤتمرات وورش عمل (Poster)
Subjects | مجال موضوع النشر: Medicine and Surgery
Divisions | الكلية: College of Medicine > Physiology
Depositing User: Prof. Ismaeel Bin-Jaliah
Date Deposited: 12 Oct 2018 13:17
Last Modified: 12 Oct 2018 13:17

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