The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight

Haidara, Mohamed and El-Karib, Abbas and Bin-Jaliah, Ismaeel and Morsy, Mohamed and Shatoor, Abdullah and Bashir, Salah and El-Gamal, Basiouny and Kemeir, Mohammed El-Hassan and Eid, Refaat (2014) The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight. Egyptian Academic Journal of Biological Sciences C. Physiology & Molecular Biology, 6 (1). pp. 83-91. ISSN 2090-0767

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Abstract|ملخص البحث

Introduction: The aim of this research is to investigate the effect of vanadium and or insulin on endothelial dysfunction in type 2 diabetic rats (T2DM). Material and methods: 60 white albino rats were included in this research and randomly divided into 6 groups(n=10) as follows: Control group (Control): rats injected once intraperitoneally (i.p.) with citrate buffer (0.1 M, pH 4.5), vanadium treated group (Vanadium): rats received vanadyl sulfate of 0.64 mmol/kg weight freshly dissolved in 1 ml of distilled water daily through a nesophageal tube, diabetic type 2group(D type 2) : rats received high fat diet for 15 days followed by streptozotocin (25 mg/kg body weight ), diabetic type 2 and insulin group (D type 2 +I): D type 2 rats received mixtard insulin subcutaneously in a dose of 0.75 IU/100 gm weight in 0.75 ml volume once daily, diabetic type 2 and vanadium group (D type 2+V): type 2 diabetic ratsreceived the same dose of vanadium as in vanadium group after 48 h of induction of type 2 diabetes, diabetic type 2 + insulin + vanadium group (D type 2 +V+I): diabetic type 2 rats received both vanadium and insulin with the same doses as in previous groups. Results: Diabetic group showed hyperglycemia, increased cholesterol(C), triglycerides (TG), LDL-C and decrease HDL-C. Administration of both insulin and vanadium caused significant decrease of glucose, TG, C, LDL-C and increased HDL-C back to control level. Histological analysis of aortae documented our results. Conclusion: Administration of vanadium enhances the effect of insulin and restore endothelial damage in T2DM.

Item Type|تصنيف النتاج العلمي: Article| منشور علمي
Subjects | مجال موضوع النشر: Medicine and Surgery
Divisions | الكلية: College of Medicine > Physiology
Depositing User: Prof. Ismaeel Bin-Jaliah
Date Deposited: 24 Jan 2019 08:05
Last Modified: 24 Jan 2019 08:05

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